Inhibition of Integrin-linked Kinase/Protein Kinase B/Akt Signaling
نویسندگان
چکیده
منابع مشابه
Integrin-linked kinase in ciliary Hedgehog signaling
Hedgehog is a conserved developmental pathway governing embryo patterning, tissue morphogenesis and differentiation. Vertebrate Hh signaling is coordinated in the primary cilium, a MT (MT)-based structure derived from the basal body (centriole) that projects singly from the surface of most cells. Defects in cilia and Hedgehog signaling cause developmental disorders affecting a range of organ sy...
متن کاملIntegrin Linked Kinase (X-ILK) Function during Embryonic Development and within Adult Tissues of Xenopus laevis
Integrin linked kinase (ILK) is a serine/threonine protein kinase implicated in the phosphatidylinositol 3’kinase (PI3’K) pathway. Integrin linked kinase has been investigated in different organisms such as mammalian systems (human, mice, rat), insects (Drosophila) and nematodes (Cenorhabditis elegans), however to date little data regarding ILK research on amphibians has been reported. In...
متن کاملInhibition of integrin-linked kinase attenuates renal interstitial fibrosis.
Integrin-linked kinase (ILK) is an intracellular serine/threonine protein kinase that regulates cell adhesion, survival, and epithelial-to-mesenchymal transition (EMT). In this study, we investigated the kinase activity of ILK during tubular EMT induced by TGF-beta1 and examined the therapeutic potential of an ILK inhibitor in obstructive nephropathy. TGF-beta1 induced a biphasic activation of ...
متن کاملEssential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling.
Integrin-linked kinase (ILK) has been implicated in the pathogenesis of proteinuria and congenital nephrotic syndrome. However, the function of ILK in glomerular podocyte in a physiologic setting remains unknown. In this study, a mouse model was generated in which ILK gene was selectively disrupted in podocytes by using the Cre-LoxP system. Podocyte-specific ablation of ILK resulted in heavy al...
متن کاملIntegrin-linked kinase regulates integrin signaling in human trabecular meshwork cells.
PURPOSE To determine whether integrin-linked kinase (ILK) controls the organization of the actin cytoskeleton in the trabecular meshwork (TM) by regulating integrin co-signaling. METHODS The cell binding domain and the Heparin II (Hep II) domain of fibronectin were used to activate α5β1 and α4β1 integrin signaling, respectively, in differentiated human TM (HTM) cells. The role of ILK was dete...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m106563200